7:02 am Pfizer, Merck KGaA ( MKGAY ), & Verastem ( VSTM ) collaborate to evaluate avelumab in combination with Verastem’s VS-6063; financial terms undisclosed ( PFE ) : The collaboration her latest blog between Merck (MKGAY), Verastem (VSTM) & Pfizer (PFE) will http://liamandersonproject.denaliinstitute.org/2016/08/02/a-click-away-from-real-world-interview-programs jointly develop/commercialize avelumab & advance Pfizer’s PD-1 antibody.Avelumab is an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in combination with Verastem’s VS-6063, an investigational focal adhesion kinase inhibitor, in patients with advanced ovarian cancer. Avelumab is currently under clinical investigation across a broad range of tumor types; Phase I/Ib clinical trial is expected to begin in the second half of 2016 Avelumab is under clinical investigation and has not been proven to be safe and effective; there is no guarantee any product will be approved in the sought-after indication by any health authority worldwide, according to Pfizer 7:02 am GTX beats by $0.06 ( GTXI ) : Reports Q4 (Dec) loss of $0.04 per share, $0.06 better than the single analyst estimate of ($0.10). ER+/AR+ breast cancer: currently expect to enroll the first stage of the open-label, Phase 2 clinical trial of enobosarm in women with metastatic or locally advanced, ER+/AR+ breast cancer by mid-year in order to report preliminary results by the end of 2016. While the first stage of the trial will evaluate 18 patients for each of the two dosing arms, 9 mg and 18 mg of enobosarm, the trial is designed to enroll up to 118 patients to obtain data from 44 evaluable patients in each study arm (a total of 88 Continued evaluable patients) to assess the primary efficacy objective of clinical benefit response following 24 weeks of treatment. AR+ TNBC: currently expect to enroll the first stage of the open-label, proof-of-concept Phase 2 clinical trial of 18 mg of enobosarm in women with advanced AR+ TNBC by mid-year in order to report preliminary results by the end of 2016. While the first stage will include 21 evaluable patients, the trial is designed to enroll up to 55 patients in total in order to obtain data from 41 evaluable patients to assess the primary efficacy objective of clinical benefit response following 16 weeks of treatment. As of December 31, 2015, cash and short-term investments were $29.3 million compared to $49.3 million at December 31, 2014. 7:02 am Cato reports Feb same store sales +4.0% vs +3.5% Retail Metrics consensus ( CATO ) : “February sales were significantly higher due to favorable sales comparisons because of the impact of weather to last year’s results.”, 7:01 am Buckle reports Feb same store sales -8.9% vs -5.9% Retail Metrics consensus (will report Q4 March 11 before the open) ( BKE ) : 6:55 am Burlington Stores lowered EPS expectations, reports revs in-line; guides Q1 EPS below consensus, revs in-line; guides FY17 ~in-line ( BURL ) : Reports Q4 (Jan) earnings of $1.49 per share, excluding non-recurring items, $0.03 better than the Capital IQ Consensus of $1.46; net sales rose 3.7% year/year to $1.54 bln vs the $1.54 bln Capital IQ Consensus. Comparable store sales increased 0.1%, which follows a comparable store sales increase of 6.7% in the Fiscal 2014 fourth quarter. Comparable store sales excluding cold weather categories increased 4.0% vs. last year. LoweredEPS to $1.44-1.46 from $1.44-1.48 with comps flat on January 11.
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. @MLauer has just spoken with @RyanLochte this evening. He’ll discuss the conversation on @NBCOlympics at 10pm ET tonight & more on TODAY. TODAY (@TODAYshow) August 18, 2016 Lochte issued an apology yesterday for not being more careful and candid in his recounting of a weekend incident in which he claims to have been robbed at gunpoint in Rio early Sunday morning. His apology came a day after Rios chief of civil police Fernando Velosa told reporters at a news conference that there was no robbery and Lochtes story was a complete fabrication. It all erupted nearly a week ago, when Lochte told NBC News Billy Bush that a man posing as a police officer pulled out a gun and put it to Lochtes forehead. He later said only that the gun was pointed at him. Lochte has since hired public relations expert Matthew Hiltzik. Gunnar Bentz, one of three other U.S. swimmers who were with Lochte at the time of the incident, yesterday released a statement of his account of what happened, backing Rio polices version of the events.
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